NAD+ IV Therapy — Cellular Energy Starts Here
NAD+ is a coenzyme found in every cell in your body. It’s essential for mitochondrial energy production, DNA repair, and the activation of sirtuins — the proteins that regulate aging at the cellular level. By your 40s, your NAD+ levels have dropped by roughly 50%. By your 60s, they’ve dropped even further. You can’t take NAD+ orally — your stomach destroys it. IV is the only way to deliver it directly into your bloodstream at therapeutic concentrations.
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Pricing
| NAD+ Option | Price | Treatment Time | Best For |
|---|---|---|---|
| NAD+ Add-On (to any IV) | Varies | Adds 15–30 min to base IV | First-timers, maintenance, adding NAD+ to a Myers or Mega Myers |
| NAD+ Standalone IV | Varies | 60–180 min depending on dose | Dedicated NAD+ therapy for anti-aging, cognitive optimization, recovery |
| High Rollers IV (includes NAD+) | $600 | 60–90 min | NAD+ bundled with high-dose vitamins, glutathione, taurine, amino blend |
*Prices may vary by state. No hidden fees. No travel fees. HSA & FSA accepted.
What NAD+ Actually Does
A lot of NAD+ marketing throws around words like “fountain of youth” and “reverse aging.” Let’s skip the hype and talk about what NAD+ actually does at the cellular level:
Mitochondrial energy production
Your mitochondria produce ATP — the energy currency of every cell. NAD+ is a required cofactor in this process. When NAD+ levels are low, your mitochondria produce less ATP. You feel it as fatigue, brain fog, and slower recovery. Restoring NAD+ levels gives your mitochondria the raw material to produce energy at a higher rate.
DNA repair
Your DNA accumulates damage every day from oxidative stress, UV exposure, and normal metabolic activity. Enzymes called PARPs use NAD+ to repair this damage. When NAD+ is depleted, DNA repair slows down, and damaged DNA accumulates. This is one of the fundamental mechanisms of aging.
Sirtuin activation
Sirtuins are a family of proteins that regulate inflammation, metabolism, stress resistance, and cellular repair. They’re sometimes called ‘longevity genes.’ Sirtuins require NAD+ to function. When NAD+ drops, sirtuin activity drops with it — and with it, your body’s ability to manage inflammation, repair damage, and maintain metabolic efficiency.
Neurotransmitter support
NAD+ plays a role in the production and regulation of neurotransmitters including dopamine, serotonin, and norepinephrine. Patients frequently report improved mental clarity, focus, and mood following NAD+ infusions. This is one of the first effects most people notice.
The honest caveat
NAD+ IV therapy is not a miracle cure. It doesn’t ‘reverse aging’ or make you 20 again. What it does is restore a critical coenzyme that your body needs for energy, repair, and cellular maintenance — a coenzyme that declines significantly with age. The research is promising and growing, but NAD+ is best understood as a tool for optimization, not a magic bullet.
Why NAD+ Has to Be IV
This is the #1 question we get about NAD+. There are oral NAD+ precursors on the market — NMN and NR (nicotinamide riboside) are the most common. Here’s the difference:
Oral precursors (NMN, NR)
These are molecules that your body can convert INTO NAD+. But the conversion process is inefficient and rate-limited by several enzymes. You take a pill, your gut absorbs some of it, your liver converts some of that into NAD+, and a fraction of the resulting NAD+ makes it to your cells. Studies show oral precursors raise NAD+ levels modestly over weeks of consistent supplementation.
IV NAD+
Delivers NAD+ directly into your bloodstream. No conversion needed. Your cells receive the finished molecule at concentrations that oral supplementation cannot achieve. Blood NAD+ levels rise immediately and significantly during the infusion. This is why patients feel effects during or shortly after treatment rather than after weeks of supplementation.
They’re not mutually exclusive
Some patients use oral NMN or NR daily for maintenance and schedule periodic NAD+ IVs (monthly or quarterly) for a therapeutic boost. This is a reasonable strategy that combines the convenience of daily supplementation with the potency of IV delivery.
Who Books an NAD+ IV?
- The longevity-focused patient. You’ve read the research on sirtuins and NAD+ decline. You understand that aging is partly a supply problem at the molecular level. NAD+ IV is the most direct way to address it.
- Patients with persistent brain fog or cognitive decline. NAD+ supports neurotransmitter production and mitochondrial function in your brain — the most energy-demanding organ in your body. Patients frequently report improved clarity, sharper thinking, and better focus as the first noticeable effect.
- Athletes over 35. Your recovery is slower than it was at 25. Part of that is NAD+ decline. Restoring levels supports mitochondrial energy production in your muscles and faster clearance of exercise-induced damage.
- Post-addiction recovery. NAD+ IV therapy has been used in addiction recovery protocols for years. Substance use depletes NAD+ stores severely, contributing to the fatigue, depression, and brain fog that make early recovery so difficult. NAD+ infusions help restore neurological function during this period.
- Chronic fatigue patients. When standard bloodwork shows nothing wrong but you’re still exhausted, mitochondrial dysfunction is a possible underlying factor. NAD+ is the most direct way to support mitochondrial energy output.
- Biohackers and optimization-focused patients.
You track your metrics, experiment with protocols, and optimize for performance. NAD+ IV is one of the few interventions that directly addresses a measurable age-related decline at the cellular level.
What to Expect During Your NAD+ Infusion
Treatment duration
NAD+ infusions take longer than standard IVs. A lower-dose add-on to an existing IV adds 15–30 minutes. A standalone high-dose NAD+ infusion can take 90–180 minutes. This is not optional — NAD+ must be administered slowly.
Why the slow drip?
Infusing NAD+ too quickly causes temporary side effects: flushing, warmth in the chest, mild nausea, muscle cramping, or a feeling of chest tightness. These effects are harmless and resolve within minutes by slowing the drip rate. Your nurse adjusts the rate to your comfort throughout the session. By the second or third infusion, most patients tolerate faster rates as their body adapts.
What you’ll feel during
Some patients feel energized during the infusion. Others feel relaxed. A warm flush or tingling sensation is common and normal. Your nurse stays with you the entire time and monitors your comfort.
What you’ll feel after
Most patients report improved mental clarity and energy within hours. Some describe it as “a fog lifting.” The effects typically build over the following 24–48 hours. Duration varies — some patients maintain benefits for 1–2 weeks, others for 3–4 weeks depending on dose, lifestyle, and baseline NAD+ levels.
Bring something to do
A book, your laptop, your phone. The treatment is comfortable but takes a while. Many patients use the time to work, read, or watch something. We come to your home or office, so you’re in your own space.
Standalone NAD+ vs. High Rollers IV
| Standalone NAD+ IV | High Rollers IV ($600) | |
|---|---|---|
| NAD+ | Yes — dedicated full dose | Yes — included in formula |
| Vitamins & Minerals | No (NAD+ only) | Yes — high-dose B vitamins, C, glutathione, zinc, magnesium |
| Taurine & Amino Blend | No | Yes |
| IV Fluids | Yes (carrier fluid) | Yes (1 liter) |
| Treatment Time | 60–180 min | 60–90 min |
| Best For | Patients who specifically want NAD+ at the highest dose, or who already supplement with vitamins and just need NAD+ | Patients who want NAD+ bundled with comprehensive vitamin, antioxidant, and amino acid support in one session |
If you want NAD+ AND full-spectrum vitamin support, the High Rollers at $600 bundles everything. If you specifically want a dedicated high-dose NAD+ infusion without additional vitamins, the standalone NAD+ IV is the focused option.
How It Works
Step 1
Book online or call/text (833) 688-1299
Let us know if you want standalone NAD+, NAD+ as an add-on, or the High Rollers IV. Same-day appointments available.
Step 2
NP reviews your health history
NAD+ requires Nurse Practitioner approval. Your NP reviews your medical background and determines the appropriate dose.
Step 3
Nurse arrives with everything needed
Your licensed RN or paramedic administers the infusion at your home, office, or hotel. They stay with you the entire session and adjust the drip rate for your comfort.
Why Pure IV for NAD+?
NP oversight matters more with NAD+
NAD+ dosing, drip rate adjustment, and side effect management require real clinical oversight. Our Nurse Practitioner reviews every NAD+ treatment. Companies that auto-approve treatments via questionnaire aren’t equipped for NAD+ infusions.
Experienced providers
NAD+ infusions are more complex than standard IVs. Our nurses have experience titrating NAD+ drip rates, managing patient comfort, and recognizing when to slow the infusion.
Physician-owned
NAD+ IV therapy should be administered under a real medical practice. Pure IV is physician-owned with the protocols and oversight to match.
We come to you
NAD+ infusions take 60–180 minutes. You don’t want to spend that in a clinic waiting room. We bring the treatment to your home or office so you can relax, work, or rest during the infusion.
FAQ's
Frequently Asked Questions
Is NAD+ IV therapy backed by science?
NAD+’s role in cellular energy production, DNA repair, and sirtuin activation is well-established biochemistry. The therapeutic application of IV NAD+ is supported by a growing body of research, particularly in aging, neurodegeneration, and metabolic function. It’s important to be realistic: NAD+ IV therapy is a legitimate intervention for cellular optimization, not a miracle anti-aging cure. The science is promising and ongoing.
How often should I get NAD+ IV therapy?
Protocols vary. Some patients start with a loading phase of 2–4 infusions over 1–2 weeks, then transition to monthly or quarterly maintenance. Others book standalone sessions as needed. Your nurse and NP can help determine the right frequency based on your goals, response, and budget.
Can I take NMN or NR supplements instead?
Oral NAD+ precursors (NMN and NR) can modestly raise NAD+ levels over weeks of consistent use. They’re a reasonable daily maintenance strategy. However, they cannot achieve the blood NAD+ concentrations that IV delivery achieves in a single session. Many patients use both: daily oral supplementation plus periodic IV infusions for a therapeutic boost.
Why does NAD+ take so long to infuse?
NAD+ causes temporary side effects when infused too quickly — flushing, warmth, nausea, or chest tightness. These effects are harmless and resolve immediately by slowing the drip rate. Administering NAD+ slowly ensures comfort and allows your body to utilize the coenzyme effectively. Your nurse adjusts the rate throughout based on your tolerance.
What does NAD+ IV feel like?
During the infusion, many patients feel a warm flush or tingling sensation, especially in the chest and abdomen. This is normal and harmless. Some patients feel energized during the session. After the infusion, the most commonly reported effects are improved mental clarity, sustained energy, and better mood — often described as “a fog lifting.”
Is NAD+ IV safe?
Yes, when administered by licensed medical professionals with proper oversight. NAD+ is a naturally occurring molecule in your body. The infusion process is the same as any IV therapy. The main considerations are drip rate (too fast causes temporary discomfort) and patient screening for contraindications. Our NP reviews every patient before treatment.
Do you accept insurance?
NAD+ IV therapy is not covered by insurance. We accept HSA/FSA cards, cash, and all major credit cards. No hidden fees or travel charges.
Restore What Time Takes Away.
Book your NAD+ IV now. Same-day service across all 10 markets.
